While human genes tend to have a start and stop site, not all gene transcripts are the same. Researchers have identified variations on this theme, which can include genes that have different start or ...

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...

In a recent review published in Nature, a group of authors reviewed the progress and challenges in annotating the human genome, including protein-coding genes, isoforms, and non-coding ribonucleic ...

Study design to create a database of transcripts, called TRAILS (TRAnscriptomic resource of Immune cells using Long-read Sequencing), from different human immune cell subsets and downstream analysis.

A process as intricate as brain development requires precisely controlled expression of crucial genes, but it’s the different flavors of a protein, or isoforms, that the genes encode that do the heavy ...

Alternative splicing (AS) is a genetic process that increases the diversity of proteins that can be generated from genes, by assembling sections of genetic code into different combinations. This is ...

Researchers have used a novel combination of short-read and long-read RNA sequencing to identify the different isoforms of genes expressed in the crustacean Daphnia magna. Males and females are ...

Researchers uncovered 214,516 unique isoforms in the developing neocortex -- over 70% of which have not been previously studied. A team led by researchers at UCLA and the University of Pennsylvania ...

Alternative splicing, a process where a single gene can give rise to multiple different proteins via inclusion or exclusion of certain segments of the gene sequence, is known to occur in over 90% of ...