http://www.bing.com:80/search?q=JCI+Notifier+Monitor+ModuleSearch resultshttp://www.bing.com:80/s/a/rsslogo.gifhttp://www.bing.com:80/search?q=JCI+Notifier+Monitor+ModuleCopyright © 2026 Microsoft. All rights reserved. These XML results may not be used, reproduced or transmitted in any manner or for any purpose other than rendering Bing results within an RSS aggregator for your personal, non-commercial use. Any other use of these results requires express written permission from Microsoft Corporation. By accessing this web page or using these results in any manner whatsoever, you agree to be bound by the foregoing restrictions.https://www.jci.org/In this issue of the JCI, Köcher et al. have demonstrated that ERG overexpression in human prostate cancer cells rewired DNA double-strand break repair toward a poly (ADP-ribose) polymerase 1–dependent (PARP1-dependent) alternative end-joining pathway without disrupting canonical repair.Thu, 26 Mar 2026 08:39:00 GMThttps://www.jci.org/kiosks/aboutEmail staff@the-jci.org or call 734-222-6050. To avoid confusion regarding correspondence, inquiries, and decisions, the JCI will typically communicate only with the responsible party/corresponding author of submissions.Tue, 14 Apr 2026 03:51:00 GMThttps://www.jci.org/archiveCopyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)Mon, 13 Apr 2026 05:18:00 GMThttps://www.jci.org/kiosks/authorsThe JCI considers research submissions in the following categories [Top of page] Click the category name for formatting instructions; or go to How to submit your manuscript for the first time (new windows). Research manuscripts provide substantial new mechanistic insights into biology and disease using preclinical models as well as materials and data derived from humans. These manuscripts are ...Mon, 13 Apr 2026 13:18:00 GMThttps://www.jci.org/kiosks/submission-firstSubmit a manuscript directly to the JCI through your account on the JCI’s submission website. Follow the instructions to either register for an account or access your existing account. Click the button below to open the submission site. Submit a manuscript to the JCI and JCI Insight simultaneously using the Dual-Journal Submission option.Sun, 12 Apr 2026 14:31:00 GMThttps://www.jci.org/top_articlesBACKGROUND Gut microbes and their metabolites contribute to the host circulating metabolome and exhibit diurnal variation influenced by sleep-wake cycles and meal timing. Sleep deprivation alters the rhythmic circulating metabolome, but its impact on microbial metabolites remains unclear. We tested whether 24-hour circulating metabolite profiles, including those of microbial origin, differ ...Mon, 13 Apr 2026 06:44:00 GMThttps://www.jci.org/articles/view/194740The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medicationsMon, 13 Apr 2026 02:12:00 GMThttps://www.jci.org/current/Konishi et al. report a unique thick microtubule bundle organization that is required to generate expansive and thin cell morphology during alveolar type 2 cell differentiation into alveolar type 1 cells. The cover image shows cultured lung pneumocyte type 1 cells with staining for acetylated tubulin (green) and nuclei (magenta). Image credit: Aleksandra Tata.Fri, 10 Apr 2026 20:02:00 GMThttps://www.jci.org/articles/view/194745Glucagon-like peptide-1 receptor agonists (GLP-1RAs), established therapies for type 2 diabetes and obesity, are increasingly recognized for their potential in neurodegenerative diseases. Preclinical studies across diverse neurodegenerative conditions consistently demonstrate neuroprotective effects of GLP-1RAs, including reduced protein aggregation, enhanced autophagy, improved mitochondrial ...Thu, 26 Mar 2026 19:44:00 GMThttps://www.jci.org/articles/view/194751View this article via: JCI Insight CrossRef PubMed Google Scholar Trevaskis JL, et al. Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice.Mon, 13 Apr 2026 12:35:00 GMT