Jul 22, 2019 · Fever of Unknown Origin (FUO) - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.

Feb 2, 2022 · FUO is not a biologically uniform phenomenon but rather a common manifestation of multiple, disparate disease processes. There are different classifications for FUO that are based on …

Immune reconstitution inflammatory syndrome is a common cause of FUO when a previously suppressed immune system is reactivated. The newly active immune system often has an …

Nov 6, 2025 · Clinicians commonly refer to a febrile illness without an initially obvious etiology as fever of unknown origin (FUO). However, most febrile illnesses either resolve before a diagnosis can be …

The approach to a patient presenting with fever of unknown origin (FUO) should include a comprehensive history, physical examination, and appropriate diagnostic testing

FUO is defined as (1) temperature ≥ 38.3°C on several occasions (2) over at least three weeks of illness and (3) uncertain diagnosis after > 1 week of study in the hospital. Traditionally divided into classic …

Fever of unknown origin (FUO) in adults poses one of the greatest diagnostic challenges in medicine.

Jul 29, 2025 · But sometimes, despite extensive investigations, the cause remains elusive. This puzzling clinical scenario is termed Fever of Unknown Origin (FUO). This detailed guide explores FUO …

Aug 14, 2023 · Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961. FUO was defined as a temperature of 101 degrees Fahrenheit (38.3 degrees Centigrade) or …

Apr 9, 2024 · Fever of unknown origin (FUO) was defined in 1961 by Petersdorf and Beeson as the following: (1) a temperature greater than 38.3°C (101°F) on several occasions, (2) more than 3 …