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  1. JCI - Welcome

    Mar 16, 2026 · In this issue of the JCI, Köcher et al. have demonstrated that ERG overexpression in human prostate cancer cells rewired DNA double-strand break repair toward a poly (ADP-ribose) …

  2. JCI - About the Journal of Clinical Investigation

    Email staff@the-jci.org or call 734-222-6050. To avoid confusion regarding correspondence, inquiries, and decisions, the JCI will typically communicate only with the responsible party/corresponding …

  3. JCI - Welcome

    Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)

  4. JCI - Author Information Center

    The JCI considers research submissions in the following categories [Top of page] Click the category name for formatting instructions; or go to How to submit your manuscript for the first time (new …

  5. JCI - Submission instructions - first

    Submit a manuscript directly to the JCI through your account on the JCI’s submission website. Follow the instructions to either register for an account or access your existing account. Click the button …

  6. JCI - The science of safety: adverse effects of GLP-1 receptor agonists ...

    Feb 16, 2026 · The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications

  7. JCI - Identification of human triple-negative breast cancer subtypes ...

    Jun 1, 2011 · Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies Brian D. Lehmann, 1 Joshua A. Bauer, 1 Xi Chen, 2 Melinda E. …

  8. JCI - Volume 136, Issue 7

    Apr 1, 2026 · Konishi et al. report a unique thick microtubule bundle organization that is required to generate expansive and thin cell morphology during alveolar type 2 cell differentiation into alveolar …

  9. JCI Insight - Welcome

    Zhang et al. report peripheral immune signatures of patients with heat stroke, identifying the NLRP3 inflammasome pathway as a potential intervention target for treatment. The cover art shows …

  10. JCI - The gut microbiome and cancer response to immune checkpoint ...

    Feb 3, 2025 · The field of the microbiome and immunotherapy has skyrocketed since 2015 when two studies demonstrated a fascinating phenomenon in mice: certain gut bacteria could enhance the …