Nov 19, 2022 · Medin, a fragment of a cell adhesion protein, forms amyloid in blood vessels. This amyloid promotes vascular amyloid-β deposits by fibrilizing with Aβ. Lowering medin protects against …

Nov 19, 2022 · The authors’ data suggests that medin generated by vascular smooth-muscle cells, and possibly other cells of the neurovascular unit, could play a role in accelerating Aβ pathology and …

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. Proc Natl Acad Sci U S A. 2020 Sep 22;117 (38):23925-23931. Epub 2020 Sep 8 PubMed.

Migrino RQ, Karamanova N, Truran S, Serrano GE, Davies HA, Madine J, Beach TG. Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia. Alzheimers Dement (Amst). …

Peng S, Larsson A, Wassberg E, Gerwins P, Thelin S, Fu X, Westermark P. Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection.

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López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023 Jan 19;186 (2):243-278. Epub 2023 Jan 3 PubMed.

Jul 29, 2023 · Change was in the air at the Alzheimer’s Association International Conference, held July 16-20 in Amsterdam. With the first treatment in 20 years having just earned traditional approval from …